Department of Population Genetics, Genomics & Bioinformatics maastricht publications

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Paulussen AD, Raes A, Jongbloed RJ, Gilissen RA, Wilde AA, Snyders DJ, Smeets HJ, Aerssens J. HERG mutation predicts short QT based on channel kinetics but causes long QT by heterotetrameric trafficking deficiency. Cardiovasc Res. 2005 Jun 13

Gielen M, Pinto-Sietsma SJ, Zeegers MP, Loos RJ, Fagard R, de Leeuw PW, Beunen G, Derom C, Vlietinck R. Birth Weight and Creatinine Clearance in Young Adult Twins: Influence of Genetic, Prenatal, and Maternal Factors. J Am Soc Nephrol. 2005 Jun 8

Lambrechts D, Devriendt K, Driscoll DA, Goldmuntz E, Gewillig M, Vlietinck R, Collen D, Carmeliet P. Low expression VEGF haplotype increases the risk for tetralogy of Fallot: a family based association study. J Med Genet. 2005 Jun;42(6):519-22

Aerssens J, Paulussen AD. Pharmacogenomics and acquired long QT syndrome. Pharmacogenomics 2005 Apr;6(3):259-70

Van Kruiningen HJ, Joossens M, Vermeire S, Joossens S, Debeugny S, Gower-Rousseau C, Cortot A, Colombel JF, Rutgeerts P, Vlietinck R. Environmental Factors in Familial Crohn's Disease in Belgium. Inflamm Bowel Dis. 2005 Apr;11(4):360-365

Yarden J, Radojkovic D, De Boeck K, Macek M Jr, Zemkova D, Vavrova V, Vlietinck R, Cassiman JJ, Cuppens H. Association of tumour necrosis factor alpha variants with the CF pulmonary phenotype. Thorax. 2005 Apr;60(4):320-5

Persu A, Vinck WJ, Khattabi OE, Janssen RG, Paulussen AD, Devuyst O, Vlietinck R, Fagard RH. Influence of the endothelial nitric oxide synthase gene on conventional and ambulatory blood pressure: sib-pair analysis and haplotype study. J Hypertens. 2005 Apr;23(4):759-765

Pierik M, De Hertogh G, Vermeire S, Van Assche G, Van Eyken P, Joossens S, Claessens G, Vlietinck R, Rutgeerts P, Geboes K. Epithelioid granulomas, pattern recognition receptors, and phenotypes of Crohn's disease. Gut. 2005 Feb;54(2):223-7

Pierik M, Yang H, Barmada MM, Cavanaugh JA, Annese V, Brant SR, Cho JH, Duerr RH, Hugot JP, McGovern DP, Paavola-Sakki P, Radford-Smith GL, Pavli P, Silverberg MS, Schreiber S, Taylor KD, Vlietinck R; for the IBD International Genetics Consortium. The IBD International Genetics Consortium Provides Further Evidence for Linkage to IBD4 and Shows Gene-Environment Interaction. Inflamm Bowel Dis. 2005 Jan;11(1):1-7

Petit MM, Meulemans SM, Alen P, Ayoubi TA, Jansen E, Van de Ven WJ. The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus. BMC Cell Biol. 2005 Jan 13;6(1):1

Smeets E, Terhal P, Casaer P, Peters A, Midro A, Schollen E, van Roozendaal K, Moog U, Matthijs G, Herbergs J, Smeets H, Curfs L, Schrander-Stumpel C, Fryns JP. Rett syndrome in females with CTS hot spot deletions: a disorder profile. Am J Med Genet A. 2005 Jan 15;132(2):117-20

Derom R, Derom C, Loos RJ, Thiery E, Vlietinck R, Fryns JP. Gender mix: does it modify birthweight - outcome association? Paediatr Perinat Epidemiol. 2005 Jan;19 Suppl 1:37-40

Loos RJ, Derom C, Derom R, Vlietinck R. Determinants of birthweight and intrauterine growth in liveborn twins. Paediatr Perinat Epidemiol. 2005 Jan;19 Suppl 1:15-22

van den Bosch BJ, van den Burg CM, Schoonderwoerd K, Lindsey PJ, Scholte HR, de Coo RF, van Rooij E, Rockman HA, Doevendans PA, Smeets HJ. Regional absence of mitochondria causing energy depletion in the myocardium of muscle LIM protein knockout mice. Cardiovasc Res. 2005 Feb 1;65(2):411-8

Vos MA, Paulussen AD. Genetic basis of drug-induced arrhythmias. Ann Med. 2004;36 Suppl 1:35-40. PMID: 15176422

Paulussen AD, Gilissen RA, Armstrong M, Doevendans PA, Verhasselt P, Smeets HJ, Schulze-Bahr E, Haverkamp W, Breithardt G, Cohen N, Aerssens J. Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients. (J Mol Med. 2004 Mar;82(3):182-8. Epub 2004 Feb 04.) PMID: 14760488

Jacobs LJ, Jongbloed RJ, Wijburg FA, de Klerk JB, Geraedts JP, Nijland JG, Scholte HR, de Coo IF, Smeets HJ. Pearson syndrome and the role of deletion dimers and duplications in the mtDNA. (J Inherit Metab Dis. 2004;27(1):47-55) PMID: 14970745

Drusedau M, Dreesen JC, De Die-Smulders C, Hardy K, Bras M, Dumoulin JC, Evers JL, Smeets HJ, Geraedts JP, Herbergs J. Preimplantation genetic diagnosis of spinocerebellar ataxia 3 by (CAG)(n) repeat detection. (Mol Hum Reprod. 2004 Jan;10(1):71-5.) PMID: 14665709

Vermeire S, Rutgeerts P, Van Steen K, Joossens S, Claessens G, Pierik M, Peeters M, Vlietinck R. Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis. (Gut. 2004 Jul;53(7):980-6.) PMID: 15194648

Zeegers MP, Rijsdijk F, Sham P, Fagard R, Gielen M, De Leeuw PW, Vlietinck R. The contribution of risk factors to blood pressure heritability estimates in young adults: the East flanders prospective twin study. (Twin Res. 2004 Jun;7(3):245-53) PMID: 15193169

Huygens W, Thomis MA, Peeters MW, Aerssens J, Janssen R, Vlietinck RF, Beunen G. Linkage of myostatin pathway genes with knee strength in humans. (Physiol Genomics. 2004 May 19;17(3):264-70. Epub 2004 Mar 16.) PMID: 15026560

Van de Putte B, Matthijs K, Vlietinck R. A social component in the negative effect of sons on maternal longevity in pre-industrial humans. (J Biosoc Sci. 2004 May;36(3):289-97.) PMID: 15164937

Thomis MA, Huygens W, Heuninckx S, Chagnon M, Maes HH, Claessens AL, Vlietinck R, Bouchard C, Beunen GP.Exploration of myostatin polymorphisms and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training. (Eur J Appl Physiol. 2004 Apr 9 [Epub ahead of print]) PMID: 15083369

Huygens W, Thomis MA, Peeters MW, Vlietinck RF, Beunen GP Determinants and upper-limit heritabilities of skeletal muscle mass and strength. (Can J Appl Physiol. 2004 Apr;29(2):186-200.) PMID: 15064427

Zeegers MP, Poppel Fv F, Vlietinck R, Spruijt L, Ostrer H. Founder mutations among the Dutch. (Eur J Hum Genet. 2004 Mar 10 [Epub ahead of print]) PMID: 15010701

Esters N, Pierik M, van Steen K, Vermeire S, Claessens G, Joossens S, Vlietinck R, Rutgeerts P. Transmission of CARD15 (NOD2) variants within families of patients with inflammatory bowel disease. (Am J Gastroenterol. 2004 Feb;99(2):299-305.) PMID: 15046221

Esters N, Pierik M, van Steen K, Vermeire S, Claessens G, Joossens S, Vlietinck R, Rutgeerts P. Transmission of CARD15 (NOD2) variants within families of patients with inflammatory bowel disease. Am J Gastroenterol. 2004 Feb;99(2):299-305. PMID: 15046221

Huygens W, Thomis MA, Peeters MW, Aerssens J, Janssen R, Vlietinck RF, Beunen G. Linkage of myostatin pathway genes with knee strength in humans. Physiol Genomics. 2004 Mar 16. PMID: 15026560

Jan R. Brants, Torik A.Y. Ayoubi, Kiran Chada, Wim J. M. Van de Ven and Marleen M. R. Petit. Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. FEBS letters, accepted for publication, 2004.

Knaapen AM, Ketelslegers HB, Gottschalk RWH, Janssen RGJH, Paulussen ADC, Smeets HJM, Godschalk R, Van Schooten FJ, Kleinjans JCS, Van Delft JHM. Simultaneous genotyping of nine polymorphisms in xenobiotic metabolizing enzymes using multiplex PCR amplification and single base extension. Submitted to Clin Chem, March 11, 2004.

Huygens W, Thomis, M.A., Peeters, M.W., Aerssens, J., Janssen, R., Vlietinck, R.F., Beunen G. (2004a) A Quantitative Trait Locus on 13q14.2 for trunk strength? J Appl Physiol. Submitted

Huygens W, Thomis, M.A., Peeters, M.W., Aerssens, J., Vlietinck, R.F., Beunen G.P. (2004b) Linkage analysis on myostatin pathway genes show three potent QTLs for human muscle strength. Am J Hum Gen. submitted and under revision.

Yarden J. RJ, De Boeck K., Macek Jr M., Zemkova D., Vavrova V., Vlietinck R., Cassiman JJ., Cuppens H. (2004) Polymorphisms in Mannose Binding Lectin affect the CF Pulmonary Phenotype. Journal of Medical Genetics. Accepted.

Nieder A, Taneja S, Zeegers M, Ostrer H. Genetic counseling for prostate cancer risk. Clin Genet. 2003 Mar;63(3):169-176. PMID: 12694223

Henskens LH, Spiering W, Stoffers HE, Soomers FL, Vlietinck RF, de Leeuw PW, Kroon AA. Effects of ACE I/D and AT1R-A1166C polymorphisms on blood pressure in a healthy normotensive primary care population: first results of the Hippocates study. J Hypertens. 2003 Jan;21(1):81-6. PMID: 12544439

Loos, R. J., C. Derom, et al. Determinants of birthweight and intrauterine growth in liveborn twins. Paediatric and Perinatal Epidemiology 2003: in press.

Langendonck L, Claessens AL, Vlietinck R, Derom C, Beunen G. Influence of Weight-bearing Exercises on Bone Acquisition in Prepubertal Monozygotic Female Twins: A Randomized Controlled Prospective Study. Calcif Tissue Int. 2003 Mar: epub ahead of print. PMID: 12616330

Derom C, Derom R, Loos RJ, Jacobs N, Vlietinck R. Retrospective determination of chorion type in twins using a simple questionnaire. Twin Res. 2003 Feb;6(1):19-21. PMID: 12626224

Zeegers MP, Jellema A, Ostrer H. Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma. Cancer. 2003 Apr;97(8):1894-903. PMID: 12673715

Maurice Zeegers, Annemarie Jellema, Harry Ostrer. Empiric risk of prostate cancer for relatives of a prostate cancer patient. Cancer. 2003; in press.

Edwin Wagena, Maurice Zeegers, Paul Knipschild. Pharmacological interventions for smoking cessation. Drug Safety. 2003; in press.

Lambrechts D, Storkebaum E, et al. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans, and protects motor neurons against ischemic death. Nat Gen 2003: in press

Stalmans I, Lambrechts D et al. VEGF: A modifier of the del22q11 (DiGeorge) syndrome? Nat Med. 2003 Feb;9(2):173-82. PMID: 12539040

Wehrens XH, Rossenbacker T, Jongbloed RJ, Gewillig M, Heidbuchel H, Doevendans PA, Vos MA, Wellens HJ, Kass RS. A Novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating. Hum Mutat. 2003 May;21(5):552. PMID: 12673799

Van Langen IM, Birnie E, Alders M, Jongbloed RJ, Le Marec H, Wilde AA. The use of genotype-phenotype correlations in mutation analysis for the long QT syndrome. J Med Genet. 2003 Feb;40(2):141-5. PMID: 12566525

Jongbloed RJ, Marcelis CL, Doevendans PA, Schmeitz-Mulkens JM, Van Dockum WG, Geraedts JP, Smeets HJ. Variable clinical manifestation of a novel missense mutation in the alpha-tropomyosin (TPM1) gene in familial hypertrophic cardiomyopathy. J Am Coll Cardiol. 2003 Mar 19;41(6):981-6. PMID: 12651045

Paulussen A, Matthijs G, Gewillig M, Verhasselt P, Cohen N, Aerssens J. Mutation analysis in congenital long QT syndrome - a case with missense mutations in KCNQ1 and SCN5A. Genetic Testing 2003;7(1):57-61.

Wagena E, Zeegers M, Van Schayck C, Wouters E. Benefits and risks of pharmacological smoking cessation therapies in chronic obstructive pulmonary disease. Drug Saf. 2003;26(6):381-403. PMID: 12688831

Dirx MJ, Zeegers MP, Dagnelie PC, Van Den Bogaard T, Van Den Brandt PA. Energy restriction and the risk of spontaneous mammary tumors in mice: A meta-analysis. Int J Cancer. 2003 Sep 20;106(5):766-70. PMID: 12866038

van der Windt DAWM, Zeegers MPA, Scholten RJPM. Systematische reviews van observationeel onderzoek. In: Offringa M., Assendelft WJJ, Scholten RJPM. Inleiding in evidence-based medicine. Bohn Stafleu Van Loghum. Houten/Antwerpen 2003.

Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL, Wyns S, Thijs V, Andersson J, Van Marion I, Al-Chalabi A, Bornes S, Musson R, Hansen V, Beckman L, Adolfsson R, Pall HS, Prats H, Vermeire S, Rutgeerts P, Katayama S, Awata T, Leigh N, Lang-Lazdunski L, Dewerchin M, Shaw C, Moons L, Vlietinck R, Morrison KE, Robberecht W, Van Broeckhoven C, Collen D, Andersen PM, Carmeliet P. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet. 2003 Jul 6 [Epub ahead of print] PMID: 12847526

Jellema A, Zeegers MP, Feskens EJ, Dagnelie PC, Mensink RP. Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies. Diabetologia. 2003 Jul;46(7):990-5. Epub 2003 Jun 18. PMID: 12819898

Van Den Brandt PA, Zeegers MP, Bode P, Goldbohm RA. Toenail selenium levels and the subsequent risk of prostate cancer: a prospective cohort study. Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):866-71. PMID: 14504196

Duijts SF, Zeegers MP, Borne BV. The association between stressful life events and breast cancer risk: a meta-analysis. Int J Cancer. 2003 Dec 20;107(6):1023-9. PMID: 14601065

Zeegers MP, Rice JP, Rijsdijk FV, Abecasis GR, Sham PC. Regression-based sib pair linkage analysis for binary traits. Hum Hered. 2003;55(2-3):125-31. PMID: 12931051

Fagard RH , Loos RJ, Beunen G, Derom C, Vlietinck R. Influence of chorionicity on the heritability estimates of blood pressure: a study in twins. J Hypertens. 2003 Jul;21(7):1313-8. PMID: 12817178

Loos RJ, Verhaeghe J, De Zegher F, Beunen G, Derom C, Fagard R, Mathieu C, Vlietinck R. Markers for cardiovascular disease in monozygotic twins discordant for the use of third-generation oral contraceptives. J Hum Hypertens. 2003 Jul;17(7):481-5.

Peeters MW, Thomis MA, Claessens AL, Loos RJ, Maes HH, Lysens R, Vanden Eynde B, Vlietinck R, Beunen G. Heritability of somatotype components from early adolescence into young adulthood: a multivariate analysis on a longitudinal twin study. Ann Hum Biol. 2003 Jul-Aug;30(4):402-18.

Alders M, Jongbloed R, Deelen W, van den Wijngaard A, Doevendans P, Ten Cate F, Regitz-Zagrosek V, Vosberg HP, van Langen I, Wilde A, Dooijes D, Mannens M.The 2373insG mutation in the MYBPC3 gene is a founder mutation, which accounts for nearly one-fourth of the HCM cases in the Netherlands. Eur Heart J. 2003; 24:1848-53

Koppens PF, Smeets HJ, de Wijs IJ, Degenhart HJ. Mapping of a de novo unequal crossover causing a deletion of he steroid 21- hydroxylase (CYP21A2) gene and a non-functional hybrid tenascin-X (TNXB) gene.J Med Genet. 2003 May;40(5):e53.

Smeets E, Schollen E, Moog U, Matthijs G, Herbergs J, Smeets H, Curfs L, Schrander-Stumpel C, Fryns JP. Rett syndrome in adolescent and adult females: clinical and molecular genetic findings. Am J Med Genet. 2003 Oct 15;122A(3):227-33. (SCI Impactfactor 7.774)

Jais JP, Knebelmann B, Giatras I, De Marchi M, Rizzoni G, Renieri A, Weber M, Gross O, Netzer KO, Flinter F, Pirson Y, Dahan K, Wieslander J, Persson U, Tryggvason K, Martin P, Hertz JM, Schroder C, Sanak M, Carvalho MF, Saus J, Antignac C, Smeets H, Gubler MC. X-linked alport syndrome: natural history and genotype-phenotype correlations in girls and women belonging to 195 families: a "European Community Alport Syndrome Concerted Action" study. J Am Soc Nephrol. 2003 Oct;14(10):2603-10.

Paulussen A, Raes A, Matthijs G, Snyders DJ, Cohen N, Aerssens J. A novel mutation (T65P) in the PAS domain of the human potassium channel HERG results in the long QT syndrome by trafficking deficiency. J Biol Chem 2002;277(50):48610-48616. PMID: 12354768

Vinck WJ, Fagard RH, Vlietinck R, Lijnen P. Heritability of plasma renin activity and plasma concentration of angiotensinogen and angiotensin-converting enzyme. J Hum Hypertens. 2002 Jun;16(6):417-22. PMID: 12037697

Vermeire S, Louis E, Rutgeerts P, De Vos M, Van Gossum A, Belaiche J, Pescatore P, Fiasse R, Pelckmans P, Vlietinck R, Merlin F, Zouali H, Thomas G, Colombel JF, Hugot JP. NOD2/CARD15 does not influence response to infliximab in Crohn's disease. Gastroenterology. 2002 Jul;123(1):106-11. PMID: 12105838

Derom C, Vlietinck R, Thiery E, Leroy F, Fryns JP, Derom R. The East Flanders Prospective Twin Survey (EFPTS). Twin Res. 2002 Oct;5(5):337-41. Review. PMID: 12537855

Loos RJ, Beunen G, Fagard R, Derom C, Vlietinck R. Birth weight and body composition in young women: a prospective twin study. Am J Clin Nutr. 2002 Apr;75(4):676-82. PMID: 11916753

Jacobs N, Rijsdijk F, Derom C, Danckaerts M, Thiery E, Derom R, Vlietinck R, van Os J. Child psychopathology and lower cognitive ability: a general population twin study of the causes of association. Mol Psychiatry. 2002;7(4):368-74. PMID: 11986980

Jacobs N, Rijsdijk F, Derom C, Danckaerts M, Thiery E, Derom R, Vlietinck R, van Os J. Child psychopathology and lower cognitive ability: a general population twin study of the causes of association. Mol Psychiatry. 2002;7(4):368-74. PMID: 11986980

Loos RJ, Phillips DI, Fagard R, Beunen G, Derom C, Mathieu C, Verhaeghe J, Vlietinck R. The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring. Diabetes Care. 2002 Dec;25(12):2191-6. PMID: 12453959

Maurice PA Zeegers, Elisabeth Dorant, R Alexandra Goldbohm, Piet A van den Brandt. A prospective study on active and environmental tobacco smoking and bladder cancer risk. Cancer Causes and Control. 2002 Feb; 13(1): 83-90. PMID: 11899922

J. Roelofs, M.L. Peters, M.P.A. Zeegers, J.W.S. Vlaeyen. The modified Stroop paradigm as a measure of selective attention towards pain-related stimuli among chronic pain patients: a meta-analysis. European Journal of Pain. 2002; 6(4): 273-281. PMID: 12161093

Maurice PA Zeegers, R. Alexandra Goldbohm, Peter Bode, Piet A van den Brandt. Prediagnostic toenail selenium and risk of bladder cancer. Cancer Epidemiology Biomarkers and Prevention. 2002 Nov; 11(11): 1292-1297. PMID: 12433705

Huygens W, Claessens AL, Thomis M, Loos R, Van Langendonck L, Peeters M, Philippaerts R, Meynaerts E, Vlietinck R, Beunen G. Body composition estimations by BIA versus anthropometric equations in body builders and other power athletes. J Sports Med Phys Fitness. 2002 Mar;42(1):45-55. PMID: 11832874

Van Den Heuvel RL, Koppen G, Staessen JA, Hond ED, Verheyen G, Nawrot TS, Roels HA, Vlietinck R, Schoeters GE. Immunologic biomarkers in relation to exposure markers of PCBs and dioxins in Flemish adolescents (Belgium). Environ Health Perspect. 2002 Jun;110(6):595-600. PMID: 12055051

Covaci A, Koppen G, Van Cleuvenbergen R, Schepens P, Winneke G, van Larebeke N, Nelen V, Vlietinck R, Schoeters G. Persistent organochlorine pollutants in human serum of 50-65 years old women in the Flanders Environmental and Health Study (FLEHS). Part 2: Correlations among PCBs, PCDD/PCDFs and the use of predictive markers. Chemosphere. 2002 Sep;48(8):827-32. PMID: 12222776

Koppen G, Covaci A, Van Cleuvenbergen R, Schepens P, Winneke G, Nelen V, van Larebeke N, Vlietinck R, Schoeters G. Persistent organochlorine pollutants in human serum of 50-65 years old women in the Flanders Environmental and Health Study (FLEHS). Part 1: Concentrations and regional differences. Chemosphere. 2002 Sep;48(8):811-25. PMID: 12222775

Wichers MC, Purcell S, Danckaerts M, Derom C, Derom R, Vlietinck R, Van Os J. Prenatal life and post-natal psychopathology: evidence for negative gene-birth weight interaction. Psychol Med. 2002 Oct;32(7):1165-74. PMID: 12420886

Jongbloed R, Marcelis C, Velter C, Doevendans P, Geraedts J, Smeets H. DHPLC analysis of potassium ion channel genes in congenital long QT syndrome. Hum Mutat. 2002 Nov;20(5):382-91. PMID: 12402336

Conrath CE, Wilde AA, Jongbloed RJ, Alders M, van Langen IM, van Tintelen JP, Doevendans PA, Opthof T. Gender differences in the long QT syndrome: effects of beta-adrenoceptor blockade. Cardiovasc Res. 2002 Feb 15;53(3):770-6. PMID: 11861047

Esters N, Pierik M, Claessens G, Joossens S, Vermeire S, Vlietinck R, Rutgeerts P. Mutations in NOD2/CARD15 in Crohn�s disease patients and their unaffected siblings. Gastroenterology 2002, 122(4):1406-1412

Esters N, Pierik M, Claessens G, Joossens G, Vermeire S, Vlietinck R, Rutgeerts P. NOD2/CARD15 mutations in a Flemish inflammatory bowel disease (IBB) population. Gastroenterology 2002, 122(4):1419.

Jacobs N, Derom C, Hanssen M, Vlietinck R, van Os J. Causes of association between three dimensions of psychosis in a general population twin sample. Acta Psychiat Scand 2002, 105:117.

Matthijs K, Van de Putte B, Vlietinck R. The inheritance of longevity in a Flemish village (18th-20th century). Eur J Pop 2002, 18(1):59-81. Loos RJF, Derom C, Eeckels R, Derom R, Vlietinck R. Gestation and birthweight in dizygotic twins � Reply. Lancet 2002,359(9301):172.

Eurlings PM, Van Der Kallen CJ, Geurts JM, Kouwenberg P, Boeckx WD, De Bruin TW. Identification of differentially expressed genes in subcutaneous adipose tissue from subjects with familial combined hyperlipidemia. J Lipid Res 2002 Jun;43(6):930-5

Duchateau, L., Janssen, P., Lindsey, P.J., Legrand, C., Nguti, R., and Sylvester, R. The shared frailty model and the power for heterogeneity tests in multicenter trials. Computational Statistics and Data Analysis 40, 2002,603-620

Kirschvink, N., Smith, N., Fievez, L., Bougnet, V., Art, T., Degand, G., Marlin, D., Roberts, C., Genicot, B., Lindsey, P.J., and Lekeux, P. Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-affected horses. Equine Veterinary Journal 34, 2002, 563-571

Beeks E, Janssen RG, Kroon AA, Keulen ET, Geurts JM, de Leeuw PW, de Bruin TW. Association between the a-adducin Gly460Trp polymorphism and systolic blood pressure in familial combined hyperlipidemia. Am J Hyperten. 2001 Dec;14(12):1185-1190. PMID: 11775124

Eurlings PM, van der Kallen CJ, Geurts JM, van Greevenbroek MM, de Bruin TW. Genetic dissection of familial combined hyperlipidemia. Mol Genet Metab. 2001 Sep-Oct;74(1-2):98-104. PMID: 11592807

Staessen JA, Nawrot T, Hond ED, Thijs L, Fagard R, Hoppenbrouwers K, Koppen G, Nelen V, Schoeters G, Vanderschueren D, Van Hecke E, Verschaeve L, Vlietinck R, Roels HA. Renal function, cytogenetic measurements, and sexual development in adolescents in relation to environmental pollutants: a feasibility study of biomarkers. Lancet. 2001 May 26;357(9269):1660-9. PMID: 11425371

Bustami R, Lesaffre E, Molenberghs G, Loos R, Danckaerts M, Vlietinck R. Modelling bivariate ordinal responses smoothly with examples from ophthalmology and genetics. Stat Med. 2001 Jun 30;20(12):1825-42. PMID: 11406844

Vinck WJ, Fagard RH, Loos R, Vlietinck R. The impact of genetic and environmental influences on blood pressure variance across age-groups. J Hypertens. 2001 Jun;19(6):1007-13. PMID: 11403347

van Larebeke N, Hens L, Schepens P, Covaci A, Baeyens J, Everaert K, Bernheim JL, Vlietinck R, De Poorter G. The Belgian PCB and dioxin incident of January-June 1999: exposure data and potential impact on health. Environ Health Perspect. 2001 Mar;109(3):265-73. PMID: 11333188

Peeters M, Joossens S, Vermeire S, Vlietinck R, Bossuyt X, Rutgeerts P. Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease. Am J Gastroenterol. 2001 Mar;96(3):730-4. PMID: 11280542

Rector A, Vermeire S, Thoelen I, Keyaerts E, Struyf F, Vlietinck R, Rutgeerts P, Van Ranst M. Analysis of the CC chemokine receptor 5 (CCR5) delta-32 polymorphism in inflammatory bowel disease. Hum Genet. 2001 Mar;108(3):190-3. PMID: 11354628

Vermeire S, Joossens S, Peeters M, Monsuur F, Marien G, Bossuyt X, Groenen P, Vlietinck R, Rutgeerts P. Comparative study of ASCA (Anti-Saccharomyces cerevisiae antibody) assays in inflammatory bowel disease. Gastroenterology. 2001 Mar;120(4):827-33. PMID: 11231936

Vermeire S, Satsangi J, Peeters M, Parkes M, Jewell DP, Vlietinck R, Rutgeerts P. Evidence for inflammatory bowel disease of a susceptibility locus on the X chromosome. Gastroenterology. 2001 Mar;120(4):834-40. PMID: 11231937

Vermeire S, Peeters M, Vlietinck R, Joossens S, Den Hond E, Bulteel V, Bossuyt X, Geypens B, Rutgeerts P. Anti-Saccharomyces cerevisiae antibodies (ASCA), phenotypes of IBD, and intestinal permeability: a study in IBD families. Inflamm Bowel Dis. 2001 Feb;7(1):8-15. PMID: 11233666

Rector A, Vermeire S, Thoelen I, Keyaerts E, Struyf F, Vlietinck R, Rutgeerts P, Van Ranst M. Analysis of the CC chemokine receptor 5 (CCR5) delta-32 polymorphism in inflammatory bowel disease. Hum Genet. 2001 Mar;108(3):190-3. PMID: 11354628

Vermeire S, Satsangi J, Peeters M, Parkes M, Jewell DP, Vlietinck R, Rutgeerts P. Evidence for inflammatory bowel disease of a susceptibility locus on the X chromosome. Gastroenterology. 2001 Mar;120(4):834-40. PMID: 11231937

Loos RJ, Beunen G, Fagard R, Derom C, Vlietinck R. Birth weight and body composition in young adult men--a prospective twin study. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1537-45. PMID: 11673778

Jacob N, Van Gestel S, Derom C, Thiery E, Vernon P, Derom R, Vlietinck R. Heritability estimates of intelligence in twins: effect of chorion type. Behav Genet. 2001 Mar;31(2):209-17. PMID: 11545537

Derom C, Groenen P, Vlietinck R. Follicle-stimulating-hormone receptor and twinning. Lancet. 2001 Jan 20;357(9251):230-1; author reply 231-2. PMID: 11213122

Loos RJ, Beunen G, Fagard R, Derom C, Vlietinck R. The Influence of Zygosity and Chorion Type on Fat Distribution in Young Adult Twins: Consequences for Twin Studies. Twin.Res. 2001 Oct;4(5):356-64. PMID: 11869489

Derom R, Bryan E, Derom C, Keith L, Vlietinck R. Twins, chorionicity and zygosity. Twin Res. 2001 Jun;4(3):134-6. PMID: 11665310

Loos RJ, Fagard R, Beunen G, Derom C, Vlietinck R. Birth weight and blood pressure in young adults: a prospective twin study. Circulation. 2001 Oct 2;104(14):1633-8. PMID: 11581141

Loos RJ, Derom C, Derom R, Vlietinck R. Birthweight in liveborn twins: the influence of the umbilical cord insertion and fusion of placentas. BJOG. 2001 Sep;108(9):943-8. PMID: 11563464

Carels C, Van Cauwenberghe N, Savoye I, Willems G, Loos R, Derom C, Vlietinck R. A quantitative genetic study of cephalometric variables in twins. Clin Orthod Res. 2001 Aug;4(3):130-40. PMID: 11553097

Jacob N, Van Gestel S, Derom C, Thiery E, Vernon P, Derom R, Vlietinck R. Heritability estimates of intelligence in twins: effect of chorion type. Behav Genet. 2001 Mar;31(2):209-17. PMID: 11545537

Loos RJ, Derom C, Eeckels R, Derom R, Vlietinck R. Length of gestation and birthweight in dizygotic twins. Lancet. 2001 Aug 18;358(9281):560-1. PMID: 11520531

Loos RJ, Beunen G, Fagard R, Derom C, Vlietinck R, Phillips DI. Twin studies and estimates of heritability. Lancet. 2001 May 5;357(9266):1445. No abstract available. PMID: 11360946

Derom C, Groenen P, Vlietinck R. Follicle-stimulating-hormone receptor and twinning. Lancet. 2001 Jan 20;357(9251):230-1; discussion 231-2. PMID: 11213122

Zeegers MPA. Risk factors for urinary bladder cancer. Maastricht. PhD Thesis, Maastricht University, 2001.

Zeegers MPA, Volovics A, Dorant E, Goldbohm RA, van den Brandt PA. Alcohol consumption and bladder cancer risk: results from the Netherlands Cohort study. American Journal of Epidemiology. 2001 Jan; 153(1): 38-41 PMID: 11159145

Zeegers MPA, Tan FES, Goldbohm RA, van den Brandt PA. Are coffee and tea consumption associated with urinary tract cancer risk? A systematic review and meta-analysis. International Journal of Epidemiology. 2001 Apr; 30(2): 353-362. PMID: 11369742

Zeegers MPA, Dorant E, Goldbohm RA, van den Brandt PA. Are coffee, tea and total fluid consumption associated with bladder cancer risk? Results from the Netherlands Cohort study. Cancer Causes and Control. 2001 Apr; 12(3): 231-238. PMID: 11405328

Zeegers MP, Swaen GM, Kant I, Goldbohm RA, van den Brandt PA. Occupational risk factors for male bladder cancer: results from a population based case cohort study in the Netherlands. Occupational and Environmental Medicine. 2001 Sep; 58(9): 590-596. PMID: 11511746

Frans ES Tan, Maurice PA Zeegers. An asymptotically unbiased estimator of exposed versus non-exposed odds ratio from reported dose-response data. Stat Methods Med Res. 2001 Oct; 10: 311-323 PMID: 11697224

Zeegers MPA, Goldbohm RA, van den Brandt PA. Consumption of vegetables and fruits and urothelial cancer incidence: a prospective study. Cancer Epidemiology Biomarkers and Prevention. 2001 Nov; 10(11): 1121-1128. PMID: 11700259

Zeegers MPA, Goldbohm RA, van den Brandt PA. Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study. British J Cancer. 2001 Sep; 85(7): 977-983. PMID: 11592769

Wagena EJ, Zeegers MPA, Huibers MJH, Chavannes NH, van Schayck CP. Bupropion: een nieuw effectief hulpmiddel bij stoppen met roken. Nederlands Tijdschrift voor Geneeskunde. 2001 Jan; 145(2): 103-104. PMID: 11225253

van Os J, Wichers M, Danckaerts M, Van Gestel S, Derom C, Vlietinck R. A prospective twin study of birth weight discordance and child problem behavior. Biol Psychiatry. 2001 Oct 15;50(8):593-9. PMID: 11690594

Wichers MC, van Os J, Danckaerts M, Van Gestel S, Derom C, Vlietinck R. Associations between nonshared environment and child problem behaviour. Soc Psychiatry Psychiatr Epidemiol. 2001 Jul;36(7):319-23. PMID: 11605999

Eerens K, Vlietinck R, Heidbuchel K, Van Olmen A, Derom C, Willems G, Carels C. Hypodontia and Tooth Formation in Groups of Children With Cleft, Siblings Without Cleft, and Nonrelated Controls. Cleft Palate Craniofac J. 2001 Jul;38(4):374-378. PMID: 11420017

van Larebeke N, Hens L, Schepens P, Covaci A, Baeyens J, Everaert K, Bernheim JL, Vlietinck R, De Poorter G. The Belgian PCB and dioxin incident of January-June 1999: exposure data and potential impact on health. Environ Health Perspect. 2001 Mar;109(3):265-73. PMID: 11333188

Lindsey, P.J. Time alignment of repeated measurements in the analyses of several veterinary clinical trials. Journal of Agricultural, Biological, and Environmental Statistics 6, 2001, 429-448.

Lindsey, J.K. and Lindsey, P.J. Detecting covariates with non-random missing values in a survey of primary education in Madagascar. Journal of the Royal Statistical Society A A164, 2001, 327-338.

Carels C, Eerens K, Heidbuchel K, Verdonck A,Willems G,Vlietinck R. Dental age and hypodontia in cleft and non-cleft siblings. J Dent Res 2001, 80(4):1299.

Peeters MW, Maes HHM, Thomis MA, Loos R, Claessens AL, Lysens R, Vanden Eynde B, Vlietinck R, Beunen GP. Evolution of genetic and environmental influences on regional fat distribution from early adolescence to young adulthood. Behav Genet 2001, 31(5):464.

Thomis MAI, Maes HHM, Peeters M, Loos R, Lysens R, Claessens AL, Vanden Eynden B, Vlietinck R, Beunen G. Genetic control of skeletal maturation during growth. Behav Genet 2001, 31(5):471

van der Loop FT, Heidet L, Timmer ED, van den Bosch BJ, Leinonen A, Antignac C, Jefferson JA, Maxwell AP, Monnens LA, Schroder CH, Smeets HJ. Autosomal dominant Alport syndrome caused by a COL4A3 splice site mutation. Kidney Int. 2000 Nov;58(5):1870-5. PMID: 11044206

Jais JP, Knebelmann B, Giatras I, De Marchi M, Rizzoni G, Renieri A, Weber M, Gross O, Netzer KO, Flinter F, Pirson Y, Verellen C, Wieslander J, Persson U, Tryggvason K, Martin P, Hertz JM, Schroder C, Sanak M, Krejcova S, Carvalho MF, Saus J, Antignac C, Smeets H, Gubler MC. X-linked Alport syndrome: natural history in 195 families and genotype-phenotype correlations in males. J Am Soc Nephrol. 2000 Apr;11(4):649-57. PMID: 10752524

van Greevenbroek MM, van der Kallen CJ, Geurts JM, Janssen RG, Buurman WA, de Bruin TW. Soluble receptors for tumor necrosis factor-alpha (TNF-R p55 and TNF-R p75) in familial combined hyperlipidemia. Atherosclerosis. 2000 Nov;153(1):1-8. PMID: 11058695

Geurts JM, Janssen RG, van Greevenbroek MM, van der Kallen CJ, Cantor RM, Bu X, Aouizerat BE, Allayee H, Rotter JI, de Bruin TW. Identification of TNFRSF1B as a novel modifier gene in familial combined hyperlipidemia. Hum Mol Genet. 2000 Sep 1;9(14):2067-74. PMID: 10958645

van der Kallen CJ, Cantor RM, van Greevenbroek MM, Geurts JM, Bouwman FG, Aouizerat BE, Allayee H, Buurman WA, Lusis AJ, Rotter JI, de Bruin TW. Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A. Int J Obes Relat Metab Disord. 2000 Nov;24(11):1381-91. PMID: 11126332

Thomis MA, Vlietinck RF, Maes HH, Blimkie CJ, van Leemputte M, Claessens AL, Marchal G, Beunen GP. Predictive power of individual genetic and environmental factor scores. Twin Res. 2000 Jun;3(2):99-108. PMID: 10918623

Vermeire S, Peeters M, Vlietinck R, Parkes M, Satsangi J, Jewell D, Rutgeerts P. Exclusion of linkage of Crohn's disease to previously reported regions on chromosomes 12, 7, and 3 in the Belgian population indicates genetic heterogeneity. Inflamm Bowel Dis. 2000 Aug;6(3):165-70. PMID: 10961588

L.M.T. Eijssen. Cluster Analysis of Microarray Gene Expression Data. MSc Thesis, Universiteit Maastricht, 2000.

van Den Bosch BJ, de Coo RF, Scholte HR, Nijland JG, van Den Bogaard R, de Visser M, de Die-Smulders CE, Smeets HJ. Mutation analysis of the entire mitochondrial genome using denaturing high performance liquid chromatography. Nucleic Acids Res. 2000 Oct 15;28(20):E89. PMID: 11024191

Procaccio V, Lescuyer P, Bourges I, Beugnot R, Duborjal H, Depetris D, Mousson B, Montfort MF, Smeets H, De Coo R, Issartel JP. Human NDUFS3 gene coding for the 30-kDa subunit of mitochondrial complex I: genomic organization and expression. Mamm Genome. 2000 Sep;11(9):808-10. PMID: 10967146

Dreesen JC, Jacobs LJ, Bras M, Herbergs J, Dumoulin JC, Geraedts JP, Evers JL, Smeets HJ. Multiplex PCR of polymorphic markers flanking the CFTR gene; a general approach for preimplantation genetic diagnosis of cystic fibrosis. Mol Hum Reprod. 2000 May;6(5):391-6. PMID: 10775641

Beunen G, Thomis M, Maes HH, Loos R, Malina RM, Claessens AL, Vlietinck R. Genetic variance of adolescent growth in stature. Ann Hum Biol. 2000 Mar-Apr;27(2):173-86. PMID: 10768422

Zeegers MPA, Tan FES, Dorant ED, van den Brandt PA. The impact of characteristics of cigarette smoking on urinary tract cancer risk quantified: a meta-analysis of epidemiological studies. Cancer. 2000 Aug; 89(3): 630-639 PMID: 10931463

van der Windt DAWM, Zeegers MPA, Kemper H, Scholten RJPM, Assendelft WJJ. De praktijk van systematische reviews: VII Zoeken, selecteren en methodologische beoordeling van observationeel onderzoek. Nederlands Tijdschrift voor Geneeskunde. 2000 Jun; 144(25): 1210-4. PMID: 10897300

Zeegers MPA, Heisterkamp SH, Kostense PJ, van der Windt DAWM, Scholten RJPM. De praktijk van systematische reviews: VIII Het combineren van de resultaten van observationele onderzoeken. Nederlands Tijdschrift voor Geneeskunde. 2000 Jul; 144(29): 1393-1397. PMID: 10923147

ter Riet G, Leffers P, Zeegers M. Scoring the quality of clinical trials. Jama. 2000 Mar; 283(11): 1421. PMID: 10732923

van der Loop FT, Monnens LA, Schroder CH, Lemmink HH, Breuning MH, Timmer ED, Smeets HJ. Identification of COL4A5 defects in Alport's syndrome by immunohistochemistry of skin. Kidney Int. 1999 Apr;55(4):1217-24. PMID: 10200983

Jongbloed RJ, Wilde AA, Geelen JL, Doevendans P, Schaap C, Van Langen I, van Tintelen JP, Cobben JM, Beaufort-Krol GC, Geraedts JP, Smeets HJ. Novel KCNQ1 and HERG missense mutations in Dutch long-QT families. Hum Mutat. 1999;13(4):301-10. PMID: 10220144

Wilde AA, Jongbloed RJ, Doevendans PA, Duren DR, Hauer RN, van Langen IM, van Tintelen JP, Smeets HJ, Meyer H, Geelen JL. Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1). J Am Coll Cardiol. 1999 Feb;33(2):327-32. PMID: 9973011

Procaccio V, Mousson B, Beugnot R, Duborjal H, Feillet F, Putet G, Pignot-Paintrand I, Lombes A, De Coo R, Smeets H, Lunardi J, Issartel JP. Nuclear DNA origin of mitochondrial complex I deficiency in fatal infantile lactic acidosis evidenced by transnuclear complementation of cultured fibroblasts. J Clin Invest. 1999 Jul;104(1):83-92. PMID: 10393702

De Coo IF, Renier WO, Ruitenbeek W, Ter Laak HJ, Bakker M, Schagger H, Van Oost BA, Smeets HJ. A 4-base pair deletion in the mitochondrial cytochrome b gene associated with parkinsonism/MELAS overlap syndrome. Ann Neurol. 1999 Jan;45(1):130-3. PMID: 9894888

de Coo RF, Buddiger PA, Smeets HJ, van Oost BA. The structure of the human NDUFV1 gene encoding the 51-kDa subunit of mitochondrial complex I. Mamm Genome. 1999 Jan;10(1):49-53. PMID: 9892733

Chitnis S, Derom C, Vlietinck R, Derom R, Monteiro J, Gregersen PK. X chromosome-inactivation patterns confirm the late timing of monoamniotic-MZ twinning. Am J Hum Genet. 1999 Aug;65(2):570-1. PMID: 10417301

Vinck WJ, Vlietinck R, Fagard RH. The contribution of genes, environment and of body mass to blood pressure variance in young adult males. J Hum Hypertens. 1999 Mar;13(3):191-7. PMID: 10204816

Schuurman AG, Zeegers MP, Goldbohm RA, van den Brandt PA. A case-cohort study on prostate cancer risk in relation to family history of prostate cancer. Epidemiology. 1999 Mar; 10(2): 192-5. PMID: 10069259

Zeegers MP, Tan FE, Verhagen AP, Weijenberg MP, van den Brandt PA. Elevated risk of cancer of the urinary tract for alcohol drinkers: a meta-analysis. Cancer Causes Control. 1999 Oct; 10(5): 445-51. PMID: 10530616

Engelen JJ, Loots WJ, Albrechts JC, Schrander-Stumpel CT, Dirckx R, Smeets HJ, Hamers AJ, Geraedts JP. Duplication within chromosome region 15q11-q13 in a patient with similarities to Prader-Willi syndrome confirmed by region-specific and band-specific fish. Genet Couns. 1999;10(2):123-32. Review. PMID: 10422004

Petit MM, Schoenmakers EF, Huysmans C, Geurts JM, Mandahl N, Van de Ven WJ. LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes. Genomics. 1999 May 1;57(3):438-41. PMID: 10329012

de Coo IF, Sistermans EA, de Wijs IJ, Catsman-Berrevoets C, Busch HF, Scholte HR, de Klerk JB, van Oost BA, Smeets HJ. A mitochondrial tRNA(Val) gene mutation (G1642A) in a patient with mitochondrial myopathy, lactic acidosis, and stroke-like episodes. Neurology. 1998 Jan;50(1):293-5. PMID: 9443499

Dreesen JC, Bras M, de Die-Smulders C, Dumoulin JC, Cobben JM, Evers JL, Smeets HJ, Geraedts JP. Preimplantation genetic diagnosis of spinal muscular atrophy. Mol Hum Reprod. 1998 Sep;4(9):881-5. PMID: 9783849

Loos R, Derom C, Vlietinck R, Derom R. The East Flanders Prospective Twin Survey (Belgium): a population-based register. Twin Res. 1998 Dec;1(4):167-75. PMID: 10100808

Buiting K, Dittrich B, Gross S, Lich C, Farber C, Buchholz T, Smith E, Reis A, Burger J, Nothen MM, Barth-Witte U, Janssen B, Abeliovich D, Lerer I, van den Ouweland AM, Halley DJ, Schrander-Stumpel C, Smeets H, Meinecke P, Malcolm S, Gardner A, Lalande M, Nicholls RD, Friend K, Horsthemke B, et al. Sporadic imprinting defects in Prader-Willi syndrome and Angelman syndrome: implications for imprint-switch models, genetic counseling, and prenatal diagnosis. Am J Hum Genet. 1998 Jul;63(1):170-80. PMID: 9634532

Geurts JM, Schoenmakers EF, Roijer E, Astrom AK, Stenman G, van de Ven WJ. Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas. Oncogene. 1998 Feb 19;16(7):865-72. PMID: 9484777

de Coo RF, Buddiger P, Smeets HJ, van Oost BA. Molecular cloning and characterization of the human mitochondrial NADH:oxidoreductase 10-kDa gene (NDUFV3). Genomics. 1997 Oct 15;45(2):434-7. PMID: 9344673

Vermeire S, Rutgeerts P, Van Steen K, Joossens S, Claessens G, Pierik M, Peeters M, Vlietinck R. Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis.Gut. 2004 Jul;53(7):980-6. PMID: 15194648

Van Larebeke N, Koppen G, Nelen V, Schoeters G, Van Loon H, Albering H, Riga L, Vlietinck R, Kleinjans J; Flemish Environment and Health Study Group.Differences in HPRT mutant frequency among middle-aged Flemish women in association with area of residence and blood lead levels.Biomarkers. 2004 Jan-Feb;9(1):71-84. PMID: 15204312

Zeegers MP, Rijsdijk F, Sham P, Fagard R, Gielen M, De Leeuw PW, Vlietinck R.The contribution of risk factors to blood pressure heritability estimates in young adults: the East flanders prospective twin study.Twin Res. 2004 Jun;7(3):245-53. PMID: 15193169

Van de Putte B, Matthijs K, Vlietinck R.A social component in the negative effect of sons on maternal longevity in pre-industrial humans.J Biosoc Sci. 2004 May;36(3):289-97. PMID: 15164937

Brants JR, Ayoubi TA, Chada K, Marchal K, Van De Ven WJ, Petit MM. Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. FEBS Lett. 2004 Jul 2;569(1-3):277-83. PMID: 15225648